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Vicki Huff, PhD

Professor, Department of Genetics, The University of Texas M. D. Anderson Cancer Center

Dr. Huff earned a Ph.D in Human Genetics from the University of Michigan. She subsequently accepted a postdoctoral fellowship to work on the genetics of childhood cancer in the laboratory of Grady Saunders in the Department of Biochemistry and Molecular Biology at M.D. Anderson Cancer Center in Houston. She is currently Professor in the Department of Genetics at MD Anderson and is a member of the Children's Oncology Group Renal Tumors Committee which carries out clinical trials and coordinates biology studies. Her research program has encompassed several disciplines and experimental approaches, including genomic analyses of human tumors; developmental biology; genetic linkage analyses; high throughput whole genome sequencing; and generation of mouse models for human diseases. Her current work focuses on identifying genes that predispose to Wilms tumor or that result in poor clinical outcome for Wilms tumor patients, understanding the role of the WT1 gene in normal development and human diseases, and investigating the possible roles of cancer stem cells and inflammation in the development of Wilms tumor and liver cancer. The ultimate goals of this work are to improve therapeutic approaches for patients, to understand how genetic changes disrupt normal cellular growth and differentiation resulting in malignancy, and to use this knowledge for understanding and improving treatment for other cancers.